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Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses. More Report Need to report the video? Rating is available when the video has been rented. Technical Navigator 1, views New. Jen Dreviews. To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface. Acer Nitro 5 Review! Sign in to report inappropriate content.

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    Involved Groups Systems Immunology.

    How to get likes on facebook page free in 1 minute - Duration: Published on Aug 26, In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

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    Autoplay When autoplay is enabled, a suggested video will automatically play next. These tasks are shared among different cell types: Cell Reports,DOI: All Time Available 3.

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    Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity.

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    Technical Navigator 1, views New. Please try again later. Premium Life 17, views. This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.

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    Walter David 47, views. To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless.

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    Safe Tricks 12, views. Chris Coursesviews. The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented antigen. If all the components of the synapse are correctly positioned, activation of the immune cell will result.

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    Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area.

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