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Functions Print Share on facebook Share on twitter. Robert, Philippos Demetriou, Michael L. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. Print Send per email Share. He and his team have recently made major breakthroughs towards this goal. T-cells red and B-cells blue form immunological synapses at their contact point green. Helmholtz - Gemeinschaft Deutscher Forschungszentren. Computer simulation of an immunological synapse with its characteristic ring-shaped structure. This, however, could not be proved for the other molecules. Dustin to simulate the formation of synapses using computer models.

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    In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

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    Today, the researchers have published their results in the scientific journal Cell Reports. This, however, could not be proved for the other molecules.

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    If all the components of the synapse are correctly positioned, activation of the immune cell will result.

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    Helmholtz - Gemeinschaft Deutscher Forschungszentren. If an immune cell recognises foreign matter, it can present it to another immune cell. Cell Reports,DOI: We use different types of cookies.

    Press Release – Helmholtz Zentrum München

    They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse. The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface.

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    The ring pattern is thus a result of mechanical forces in the cell membrane which sorts the molecules in the synapse according to their size. The antigen receptors are small and are repelled by the large adhesion molecules. If all the components of the synapse are correctly positioned, activation of the immune cell will result. Dustin to simulate the formation of synapses using computer models.

    We only use this information for improving our services. If an immune cell recognises foreign matter, it can present it to another immune cell. This, however, could not be proved for the other molecules.

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    Dustin to simulate the formation of synapses using computer models.

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    Imprint De utsch En glish. Since quality deviations can have a direct impact on the health of consumers, quality assurance plays a key role in pharmaceutical manufacturing. Statistical cookies Matomo Permit cookies that help us to analyse the page views and user behavior on our websites. Today, the researchers have published their results in the scientific journal Cell Reports.

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    Since quality deviations can have a direct impact on the health of consumers, quality assurance plays a key role in pharmaceutical manufacturing.

    In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.

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    Robert, Philippos Demetriou, Michael L. Necessary cookies Only cookies permitted that are required for the basic functionality of our websites.

    Dustin to simulate the formation of synapses using computer models. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.

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    To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless.

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    By using our website, you agree to the use of cookies. Statistical cookies Matomo Permit cookies that help us to analyse the page views and user behavior on our websites. Necessary cookies Only cookies permitted that are required for the basic functionality of our websites. Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed.

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    2. We use cookies to improve your experience on our Website. In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.

    3. We use different types of cookies. Semb aims to develop safe approaches for up-scaled production of insulin-producing beta cells from human pluripotent stem cells hPSCs.